Precedex Indications and Usage
Precedex is indicated for:
- Sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Administer Precedex by continuous infusion not to exceed 24 hours.
- Sedation of non-intubated patients prior to and/or during surgical and other procedures.
Precedex Important Safety Information
Please see full Prescribing Information
- Monitoring: Continuously monitor patients while receiving Precedex.
- Bradycardia and Sinus Arrest: Have occurred in young healthy volunteers with high vagal tone or with different routes of administration, e.g., rapid intravenous or bolus administration.
- Hypotension and Bradycardia: May necessitate medical intervention. May be more pronounced in patients with hypovolemia, diabetes mellitus, or chronic hypertension, and in the elderly. Use with caution in patients with advanced heart block or severe ventricular dysfunction.
- Co-administration with Other Vasodilators or Negative Chronotropic Agents: Use with caution due to additive pharmacodynamic effects.
- Transient Hypertension: Observed primarily during the loading dose. Consider reduction in loading infusion rate.
- Arousability: Patients can become aroused/alert with stimulation; this alone should not be considered as lack of efficacy.
- Prolonged exposure to dexmedetomidine beyond 24 hours may be associated with tolerance and tachyphylaxis and a dose-related increase in adverse events.
- The most common adverse reactions (incidence > 2%) are hypotension, bradycardia, and dry mouth.