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Precedex ®

US Intended for U.S. audiences

Indications and Safety Information

Precedex is indicated for sedation in nonintubated patients prior to and during surgical and other procedures and in intubated and mechanically ventilated patients during treatment in an intensive care setting.

Precedex should be administered by continuous infusion not to exceed 24 hours.

Caution should be exercised when administering Precedex to patients with advanced heart block and/or severe ventricular dysfunction.

Clinically significant episodes of bradycardia, sinus arrest and hypotension have been associated with Precedex infusion and may necessitate medical intervention.

Please see a more complete description of these and other Warnings and Precautions in the full prescribing information.

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References

  1. Precedex [package insert]. Lake Forest, IL: Hospira, Inc; 2012.
  2. Martin E, Ramsay G, Mantz J, Sum-Ping STJ. The role of the α2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med. 2003;18:29-41.
  3. Herr DL, Sum-Ping STJ, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003;17(5):576-584.
  4. Candiotti KA, Bergese SD, Bokesch PM, et al. Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesth Analg. 2010;110(1):47-56.
  5. Data on file, #2. Hospira, Inc.
  6. Data on file, #7. Hospira, Inc.
  7. Fragen RJ, Fitzgerald PC. Effect of dexmedetomidine on the minimum alveolar concentration (MAC) of sevoflurane in adults age 55 to 70 years. J Clin Anesth. 1999;11(6):466-470.
  8. Karol M, Maze M. Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans. Best Pract & Res Clin Anaesthesiol. 2000;14(2):261-269.
  9. Aantaa R, Jaakola ML, Kallio A, Kanto J. Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine. Anesthesiology. 1997;86(5):1055-1060.
  10. Dutta S, Karol MD, Cohen T, Jones RM, Mant T. Effect of dexmedetomidine on propofol requirements in healthy subjects. J Pharm Sci. 2001;90(2):172-181.
  11. Unlugenc H, Gunduz M, Guler T, Yagmur O, Isik G. The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine. Eur J Anaesthesiol. 2005;22(5):386-391.
  12. Hospira Clinical Study Report 2005-005.
  13. Data on file, #3. Hospira, Inc.
  14. Hospira Clinical Study Report W99-302.
  15. Data on file, #4. Hospira, Inc.
  16. Robinul [package insert]. Deerfield, IL: Baxter Healthcare Corporation; 2007.
  17. Atropine [package insert]. Lake Forest, IL: Hospira, Inc; 2006
  18. Ephedrine [package insert]. Lake Forest, IL: Hospira, Inc; 2004.