Precedex is the only alpha₂ agonist indicated for sedation. Precedex exerts its effects via the alpha₂-adrenoceptor. Thus, Precedex has a different mechanism of action that is not GABA-mimetic like that of propofol or a benzodiazepine.

It is important to be aware of the clinical differences you may see with Precedex. This section explains these differences and sets clinical expectations for this IV sedative agent.

For a perspective from two clinicians on what to expect with Precedex, click on the following video.

Presented by:

• Christopher Young, MD, Chief of Critical Care Medicine (Department of Anesthesiology) at Duke University Medical Center in Durham, North Carolina.
• Dan Herr, MD, an Intensivist at Washington Hospital Center in Washington, DC.