Precedex Logo
Precedex ®

US Intended for U.S. audiences

Indications and Safety Information

Precedex is indicated for sedation in nonintubated patients prior to and during surgical and other procedures and in intubated and mechanically ventilated patients during treatment in an intensive care setting.

Precedex should be administered by continuous infusion not to exceed 24 hours.

Caution should be exercised when administering Precedex to patients with advanced heart block and/or severe ventricular dysfunction.

Clinically significant episodes of bradycardia, sinus arrest and hypotension have been associated with Precedex infusion and may necessitate medical intervention.

Please see a more complete description of these and other Warnings and Precautions in the full prescribing information.

button

Time to Onset

Following a loading infusion of 1 mcg/kg given over 10 minutes to healthy volunteers, the sedative effects of Precedex were observed in 10 to 15 minutes. If a loading dose is not used, time to onset of the sedative effect may be extended.5

This is important to know so that preexisting sedative agents or analgesics are not titrated downward too quickly before the sedative effects of Precedex have taken effect, or too slowly, such that patients are oversedated.5

Patients can be evaluated 15 to 25 minutes after initiating Precedex therapy or 20 to 30 minutes after each dosage adjustment to determine if adequate sedation, analgesia and patient comfort have been maintained.5

Time to sedative onset with Precedex in healthy normal subjects5